Purine nucleotides
Apexbio Technology LLC LDE225 Diphosphate 1218778-77-8 5mg
LDE225 Diphosphate (CAS 1218778-77-8) is a highly potent and selective antagonist of the Smoothened (Smo) receptor a seven-transmembrane protein involved in the Hedgehog (Hh) signaling pathway LDE225 inhibits Smo with IC50 values of 1 3 nM for murine and 2 5 nM for human Smo resulting in suppression of Hh signaling This pathway is implicated in cellular differentiation proliferation and oncogenesis In vitro LDE225 selectively binds Smo inhibiting Hh-dependent tumor cell growth In vivo it demonstrates dose-dependent antitumor efficacy in medulloblastoma xenograft mouse models LDE225 continues to be explored as a research tool and therapeutic candidate in Hh pathway-driven malignancies
Apexbio Technology LLC Primaquine Diphosphate 63-45-6 10g
Primaquine Diphosphate is an 8-aminoquinoline derivative utilized primarily as an antimalarial agent targeting the extraerythrocytic liver stage of malaria parasites While its precise IC50 values remain unspecified primaquine s biological activity involves interference with nucleic acid function subsequently disrupting protein synthesis pathways and lipid biosynthesis and inducing membrane disturbances In vitro primaquine has been applied in cell culture models to investigate antiviral effects demonstrating dose-dependent inhibition of Newcastle disease virus replication and modulation of viral RNA synthesis In vivo experiments using radiolabeled primaquine-loaded liposomes in murine models illustrate pronounced hepatic accumulation Clinically this compound is employed as prophylaxis against malaria infections (e g Plasmodium falciparum and P vivax)
Medchemexpress LLC Adenosine 5′-diphosphoribose | 20762-30-5 | 98.2% | 559.32 | C15H23N5O14P2 | 25 MG
Adenosine 5′-diphosphoribose is an endogenous nucleotide derivative used in biochemical and cell biology research to study ADP-ribosylation, DNA damage responses, and TRPM2 channel activation. Supplied as a light yellow powder with defined solubility and storage recommendations, it is suitable for in vitro assays and biochemical experiments.
- Biologically active endogenous nucleotide derivative.
- High purity suitable for biochemical assays (98.2%).
- Light yellow powder form for convenient handling and storage.
- Water soluble (175 mg/mL; ultrasonic may be required for dissolution).
- Stable as a powder at -20°C for long-term storage; in solvent stability is limited.
- Supplied in small research-scale quantities for laboratory use.
Sigma Aldrich Fine Chemicals Biosciences Chloroquine diphosphate sa250G
Chloroquine is a member of quinolone family and is a weak intercalating agent. Chloroquine is used for treating amebiasis rheumatoid arthritis discoid and systemic lupus erythematosus.
Medchemexpress LLC GTP-14564 | 34823-86-4 | MFCD01416326 | 99.9% | 234.25 g·mol⁻¹ | C15H10N2O | 5 MG
GTP-14564 is a small-molecule tyrosine kinase inhibitor selective for internal tandem duplication (ITD) mutant and wild-type FLT3. It inhibits FLT3 ligand-dependent proliferation of Ba/F3 leukemia cells and is used as a research tool to study FLT3-driven signaling and leukemogenesis. Chemical formula C15H10N2O; molecular weight 234.25 g·mol⁻¹; reported purity 99.91%.
- Targets ITD and wild-type FLT3.
- Inhibits FLT3 ligand-dependent growth in Ba/F3 cells.
- High reported purity suitable for biochemical assays.
- Compact quantity suitable for screening and small-scale studies.
- Documented in chemical databases and literature for FLT3 research.
Medchemexpress LLC Adenosine 5'-diphosphoribose | 20762-30-5 | 98.2% | 559.32 g/mol | C15H23N5O14P2 | 5 MG
Adenosine 5'-diphosphoribose is an endogenous nucleotide (ADP ribose) consisting of an adenine base linked to a ribose and two phosphate groups. Supplied as a research-grade solid, it is used in biochemical and cellular assays to investigate ADP-ribosylation signaling, DNA damage response pathways, and calcium-permeable TRPM2 channel activation. The material is provided in assay-friendly quantities with supporting documentation for safe handling.
Cambridge Isotope Laboratories URIDINE DIPHOSPHATE-D-GLUCOSE
NC3591782 URIDINE DIPHOSPHATE-D-GLUCOSE
Cambridge Isotope Laboratories Adenosine 5-triphosphate ammonium salt (15N5 98-99%) CP 90% (in solution) 20 umol
Adenosine 5-triphosphate ammonium salt (15N5 98-99%) CP 90% (in solution) 20 umol
Sigma Aldrich Fine Chemicals Biosciences Adenosine-13C1015N5 5-mono1MG
REAGENT Adenosine-13C1015N5 5-mono1MG
Cambridge Isotope Laboratories Uridine diphosphate-Alpha-D-glucose NH4 salt (glucose-1 2 3 4 5 6 -13C6 99%) in solution CP 95% 100 umol
Uridine diphosphate-Alpha-D-glucose NH4 salt (glucose-1 2 3 4 5 6 -13C6 99%) in solution CP 95% 100 umol